Spotted bone disease (osteopoikilosis)

  • Mimi O
  • Asnida AAR
  • Abdul Malik MH
  • Norita M


We report here a rare case of osteopoikilosis which presented in a male Punjabi teenager. Osteopoikilosis is defined as ‘an asymptomatic, autosomal dominant trait in which pea-sized sclerotic spots are prominent in the metaphyseal area’.1 It is also known as Buschke-Ollendorf Syndrome, dermatofibrosis lenticularis, disseminated dermatofibrosis, osteodermatopoikilosis, osteopathic condensans disseminata and spotted bone disease. This is the second case of osteopoikilosis that has been documented in Malaysia. (copied from article)


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Tachdjian MO. Osteopoikilosis (Spotted Bones). In: Wicklang EH Jr. Paediatric Orthopaedics. 2nd ed. Philadelphia: W.B.Saunders; 1990:815-6.

Mindell ER., Northup CS, Douglass HO Jr. Osteosarcoma associated with osteopoikilosis. J Bone Joint Surg. 1978 Apr;60(3):406-8.

Pan KL, Ibrahim S. Osteopoikilosis – a case report. Med J Malaysia. 2000 Sep;55 Suppl C:107-8.

How to Cite
OM., AARA., MHA. M., & MN. (2012). Spotted bone disease (osteopoikilosis). Malaysian Family Physician, 13(3), 1. Retrieved from
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