Common laboratory tests for rheumatological disorders: How do they help the diagnosis?
AbstractNo screening test is ideal for detecting rheumatic diseases; diagnosis depends on appropriate history and thoroughphysical examination. Sometimes, laboratory investigations may be useful in confirming or ruling out rheumatic diseaseafter a clinical diagnosis is considered. Once a rheumatic disease has been diagnosed, certain laboratory tests canhelp in assessing prognosis or determining the extent of the disease. Laboratory tests may also help the physicianmonitor certain rheumatic diseases, guide treatment or assess potential drug toxicity.
Clarke A. The burden of rheumatic disease. Medicine. 2006;34(90):333-5.
Taylor W, Smeets L, Hall J, et al. The burden of rheumatic disorders in general practice: consultation rates for rheumatic disease and the relationship to age, ethnicity, and small-area deprivation. N Z Med J. 2004;117(1203) U1098.
Sox HC Jr, Liang MH. The erythrocyte sedimentation rate: guidelines for rational use. Ann Intern Med. 1986;104(4):515-23.
Miller A, Green M, Robinson D. Simple rule for calculating normal erythrocyte sedimentation rate. BMJ. 1983;286(6361): 266.
Chen P. Rheumatoid factor. Rheum Dis Clin. 1989;13:545.
Lichtenstein MJ, Pincus T. Rheumatoid arthritis identified in population-based cross sectional studies: low prevalence of rheumatoid factor. J Rheumatol. 1991;18(7):989-93.
Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146(11):797-808.
Kushner I. C-reactive protein in rheumatology. Arthritis Rheum. 1991;34(8):1065-8.
Tan EM, Feltkamp TE, Smolen JS, et al. Range of antinuclear antibodies in “healthy” individuals. Arthritis Rheum. 1997; 40(9):1601-11.
ter Borg EJ, Horst G, Hummel EJ, et al. Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus: a long-term, prospective study. Arthritis Rheum. 1990;33(5):634-43.
Esdaile JM, Abrahamowicz M, Joseph L, et al. Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus: why some tests fail. Arthritis Rheum. 1996;39:370-8.
Hall AP, Barry PE, Dawber TR, et al. Epidemiology of gout and hyperuricemia: a long-term population study. Am J Med. 1967;42(1):27-37.
Pittman JR, Bross MH. Diagnosis and management of gout. Am Fam Physician. 1999;59(7):1799-806,1810.
Love LA, Leff RL, Fraser DD, et al. A new approach to the classification of idiopathic inflammatory myopathy: myositisspecific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore). 1991;70(6):360-74.
Niles JL. Value of tests for antineutrophil cytoplasmic autoantibodies in the diagnosis and treatment of vasculitis. Curr Opin Rheumatol. 1993;5(1):18-24.