Fish oil to prevent heart disease: the evidence and the controversy
AbstractIn November 2002, the American Heart Association, after a comprehensive review, announced that fish oil reduces heart disease and recommended that patients consume daily 1gram of marine derived omega-3 fatty acids (comprising eicosapentaenoic acid, EPA, and docosahexaenoic acid, DHA).1 Yet, the BMJ recently published a report suggesting that fish oil is of no value in heart disease.2 What are we to believe, and does omega-3 really protects against heart disease? (copied from article)
Kris-Etherton PM, Harris WS Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106:2747-57.
Hooper L, Thompson RL, Harrison RA, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ. 2006;332:752-60.
Daviglus ML, Stamler J, Orencia AJ, et al. Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med.1997;336:1046-53.
Hu FB, Bronner L, Willett WC, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA. 2002;287:1815-21.
He K, Rimm EB, Merchant A, et al. Fish consumption and risk of stroke in men. JAMA. 2002;288:3130-6.
GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Lancet. 1999;354:447-55.
von Schacky C, Angerer P, Kothny W, et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis: A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1999;130:554-62.
Bucher HC, Hengstler P, Schindler C, et al. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med. 2002;112(4):298-304.
Studer M, Briel M, Leimenstoll B, et al. Effect of different antilipidemic agents and diets on mortality. Arch Intern Med. 2005;165:725-30.
DeFilippis AP, Sperling LS. Understanding omega-3’s. Am Heart J.2006;151:564-70.
Burr ML, Ashfield-Watt PAL, Dunstan FDJ, et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clinl Nutr. 2003;57:193-200.
Wang C, Chung M, Lichtenstein A, et al. Effects of omega-3 fatty acids on cardiovascular disease. Summary, Evidence Report/Technology Assessment: Number 94. AHRQ Publication Number 04-E009-1, March 2004. Agency for Healthcare Research and Quality, Rockville, MD.