Ptosis due to cavernous sinus syndrome as a rare presentation of advanced breast metastasis in a patient with delayed diagnosis

  • KW Khaw
  • N Ramli
  • K Rahmat


Complications of breast cancer metastasis may be the first manifestation of the disease. We report a rare case of left eye ptosis secondary to cavernous sinus syndrome in a 34-year-old lady due to refusal of proper medical treatment for metastatic breast cancer. The delay in seeking medical treatment was attributed to her use of Traditional Chinese Medicine (TCM).


Fernandez S, Godino O, Martınez-Yelamos S, et al. Cavernous sinus syndrome: a series of 126 patients. Medicine (Baltimore). 2007;86(5):278-81.

Ryan MW, Rassekh CH, Chaljub G. Metastatic breast carcinoma presenting as cavernous sinus syndrome. Ann Otol Rhinol Laryngol. 1996;105(8):666-8.

Martin Polo J, Rivas López T, Martin Polo R, et al. Cavernous sinus syndrome: an initial expression of a breast carcinoma. Neurologia. 2005;20(3):153-5.

Frympas G, Televantou D, Papageorgiou V, et al. Unsuspected breast carcinoma presenting as orbital complication of rhinosinusitis. Eur Arch Otorhinolaryngol. 2008;265(8):979-82.

Hisham AN, Yip CH. Overview of breast cancer in Malaysian women: a problem with late diagnosis. Asian J Surg. 2004;27(2):130-3.

Lee MM, Lin SS, Wrensch MR, et al. Alternative therapies used by women with breast cancer in four ethnic populations. J Natl Cancer Inst. 2000;92(1):42-7.

Cui Y, Shu XO, Gao Y, et al. Use of complementary and alternative medicine by chinese women with breast cancer. Breast Cancer Res Treat. 2004:85(3);263-70.

Facione NC, Giancarlo C, Chan L. Perceived risk and help-seeking behavior for breast cancer. A Chinese-American perspective. Cancer Nurs. 2000;23(4):258-67.

Taib NA, Yip CH, Ibrahim M, et al. Breast cancer in Malaysia: are our women getting the right message? 10-year experience in a single institution in Malaysia. Asian Pac J Cancer Prev. 2007;8(1):141-5.

Jacobson JS, Workman SB, Kronenberg F. Research on complementary/alternative medicine for patients with breast cancer: a review of the biomedical literature. J Clin Oncol. 2000;18(3):668-83.

Cohen I, Tagliaferri M, Tripathy D. Traditional Chinese medicine in the treatment of breast cancer. Semin Oncol. 2002;29(6):563-74.

Goldbeck R. Denial in physical illness. J Psychosom Res. 1997;43(6):575-93.

Mohamed IE, Skeel Williams K, Tamburrino M, et al. Understanding locally advanced breast cancer: what influences a woman’s decision to delay treatment. Prev Med. 2005;41(2):399-405.

How to Cite
KhawK., RamliN., & RahmatK. (2012). Ptosis due to cavernous sinus syndrome as a rare presentation of advanced breast metastasis in a patient with delayed diagnosis. Malaysian Family Physician, 7(1), 3. Retrieved from
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